Compare Fractions: Find the Symbol Between 2/8 ☐ 4/16

We need to compare the fractions $\frac{2}{8}$ and $\frac{4}{16}$. To do this, we'll simplify each fraction to see if they are equal or if one is greater than the other.

Step 1: Simplify $\frac{2}{8}$
To simplify, find the greatest common divisor (GCD) of 2 and 8, which is 2. Divide the numerator and denominator by this GCD:
$\frac{2}{8} = \frac{2 \div 2}{8 \div 2} = \frac{1}{4}$

Step 2: Simplify $\frac{4}{16}$
Similarly, find the GCD of 4 and 16, which is 4. Divide both the numerator and denominator by this GCD:
$\frac{4}{16} = \frac{4 \div 4}{16 \div 4} = \frac{1}{4}$

Both fractions simplify to $\frac{1}{4}$. Thus, they are equal.

Conclusion:
Since the simplified forms of both fractions are equal, the correct sign to fill in is $=$.

Therefore, the solution to the problem is $=$.